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In 2007, she won an Emmy award for her role as Izzie Stevens, but, after the next season of the show, she refused to submit her name for Emmy consideration, saying that she didn't think she was "given the material this season to warrant an Emmy nomination," as reported by ), saying, "I am done," noting, "We just finalized our agreement.Everyone had been working really hard to find an amicable and gracious way of letting go and moving on.Alex Karev, played by Justin Chambers, started as a moody intern, and is now a senior member of the surgical team.

Shonda Rhimes seemed just as devastated about the decision, saying, "One of the best days of my life as a writer happened the day Sandra Oh walked in my door to audition and forever changed the course of series regulars would be leaving the show: Tessa Ferrer, who played Dr. Ferrer's Leah was a second-year resident who had dated both Alex Karev (played by Justin Chambers) and Arizona Robbins (played by Jessica Capshaw).Viewers have seen a lot of their favorite doctors come and go, and the reasons why the cast members themselves have left are always interesting.Whether it's because of a change in direction for the show's plot or behind-the-scenes drama, there's a story behind each actor's departure.has now been on for an astounding 15 seasons and was recently renewed for Seasons 16 and 17, with 16 starting in the fall.As you would imagine, there has been quite a lot of turnover in the cast over the years, as is usually the case with shows that endure for as long as Incredibly, it is worth noting that the show of the nine original main cast members, four are still with the show and have appeared in every season, including the star, Ellen Pompeo, who of course plays Meredith Grey.

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